AZABU UNIVERSITY
School of Veterinary Medicine
Professor  Dr. Masaharu Hisasue

We are researching simple and low-cost production of canine liver organoids using a culture method using low molecular weight compounds, the only one in the world. This liver organoid has the potential to assess drug and chemical toxicity.

IBARAKI UNIVERSITY
Department of Agriculture
Specially Appointed Professor  Dr. Kazuichi Sakamoto

We study on natural bio-active substances (phytochemicals, etc) which act on wellness and anti-aging by using novel bio-assay system. We also apply them to functional foods and cosmetics under the co-operation with companies.

SHINSHU UNIVERSITY
Research Center of Colloid and Interface Science
Director  Dr. Toshio Sakai

We developed the emulsification and stabilization technique in the absence of anysurfactants and emulsifiers (named as surfactant- and/or emulsifier-free emulsification: EfE).

KOBE COLLEGE
School of Human Sciences
Professor  Dr. Naofumi Shiomi

Pluripotent stem cells (PIS cells) obtained by adding high concentrations of polyamines to normal somatic cells can be differentiated to neural stem cells and cardiomyocytes, and are expected to be used in medicine.

KYOTO UNIVERSITY
Graduate School of Biostudies
Professor  Dr. Akira Kakizuka

We have successfully developed compound cocktails that dramatically enhance the production efficiency of biologics. We have also succeeded in developing expression vectors that could maximize the effects of these compound cocktails.

GIFU PHARMACEUTICAL UNIVERSITY
Laboratory of Biochemistry, Department of Biopharmaceutical Sciences
Associate professor  Dr. Satoshi Endo

We found novel inhibitors of DDI2, which is involved in a proteasome bounce-back response, and demonstrated their potential as adjuvant agents.

NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECHNOLOGY
Department of Advanced Functional Materials Research
Deputy Director  Dr. Mitsumasa Taguchi

We are conducting research and development of cutting-edge medical devices such as microphysiological system to evaluate the effects of drugs and others.

OSAKA UNIVERSITY
Graduate School of Pharmaceutical Science
Specially Appointed Professor  Dr. Hiroaki Adachi

MA-T can be applied to a wide range of applications. In this presentation, we will introduce the application to anticancer drugs. In addition, we have developed and commercialized a real-time observation device for electrophoresis.

DOSHISHA UNIVERSITY
Faculty of Life and Medical Sciences
Professor  Dr. Yusuke MORITA

We developed the nano/micro-structured functional fiber scaffolds that enable to maintain cell activity and reproduce in vivo environment, and the cell fabric constructed with the cell-enclosing alginate microfiber.

KANAZAWA UNIV.
Division of Marine Environmental Studies,
Prof. Emeritus  Dr. Masanori Somei

There are many types of skin troubles and corresponding cosmetics and drugs are commercially available. We have succeeded in developing a multifunctional organic compound "VED" that can deal with almost all troubles.

NAGOYA UNIVERSITY
HVEM Laboratory
Associate Professor  Dr. Shigeo Arai

Introduction of the MEXTs ARIM Project Next-Generation Biomaterial s. We will introduce electron microscope technology, which is indispensable for biomaterial research and technological development, and introduce examples of results.

NARO
HARC
Principal Researcher  Dr. Naoya TAKAKUWA

A total of approximately 2,800 strains of yeasts were isolated from several plant sources in Hokkaido.

SHINSHU UNIVERSITY
Faculty of Agriculture
Professor  Dr. ISAO KII

"Temperature Jump," a technology that turns undruggable disease-related proteins into druggable ones is presented. This technology is based on the thermodynamic fluctuation of the protein structure.

SOPHIA UNIVERSITY
Department of Materials and Life Sciences, Faculty of Science and Technology
Professor  Dr. Jiro Kondo

We will present our technologies of RNA molecular design, crystallization, and structural analysis for realizing "RNA-targeted drug discovery" and "RNA therapeutics," as well as examples of drug development using them.

TOKUSHIMA UNIVERSITY
Institute of Post-LED Photonics
Professor  Dr. Takaaki Yano

We present various types of highly sensitive optical biosensing techniques using optical nanostructures, opening a new window for early and rapid diagnostics.

NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory
Deputy director  Dr. Hisashi Anbutsu

AIST and Waseda University established a fusion laboratory (OIL) in 2016 to analyze various life system
data with informatics techniques. In this presentation, I will introduce the various research being conducted
in the OIL.

OSAKA UNIVERSITY
Grad. Sch. of Pharmaceutical Science
Professor  Dr. Tsuyoshi Inoue

One of the difficult reactions, methane oxidation reaction discovered based on the mechanism of MA-T was applied to the oxidative modification of graphene grids for cryo-electron microscopy to develop a protein immobilization tool.

SHINSHU UNIVERSITY
Faculty of Textile Science and Technology
Professor  Dr. Yoshitake Akiyama

A cryoprotectant agent is essential for conventional cell cryopreservation. In this presentation, we introduce the world's first cryoprotectant agent-free cryopreservation technique by ultraflashfreezing using inkjet printed microdroplets.

CHUO UNIVERSITY
Department of Physics
Professor  Dr. Y-h. Taguchi

Conventional supervised machine learning is impossible without a large number of teacher data. To improve this point, we propose a method using unsupervised learning that does not require teacher data.

KEIO UNIVERSITY
School of Medicine, Department of Surgery
Assistant Professor  Dr. Hiroshi Yagi

The extracellular matrix hydrogels were originally developed from several types of decellularized porcine tissues. The tissue-derived hydrogels effectively functioned as the scaffolds for the guided regeneration of organs such as kidney.

NIHON UNIVERSITY
School of Medicine
Professor  Dr. Chiaki HIDAI

The product is a peptide derived from blood coagulation factor IX. It inhibits the response of cultured cells to interleukin-6 and thrombin stimulation, the substances responsible for the inflammatory response in patients with ARDS.

OSAKA UNIVERSITY
SANKEN
Associate Professor  Dr. Shinobu Takizawa

In the drug synthesis, the number of searches increases exponentially as the number of reaction condition parameters increases. Herein, I will introduce the optimization of reaction conditions by machine learning with minimal learning data.

TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES
Department of Clinical Biochemistry
Assistant professor  Dr. Keisuke Hamada

We developed a bispecific DNA aptamer-based lysosome-targeting chimera for HER2 protein degradation (HER2-LYTAC). This study points to the possibility of HER2-LYTAC as a next-generation of therapeutic agent for HER2-positive cancer.

AZABU UNIVERSITY
School of Veterinary Medicine
Associate Professor  Dr. Tomoki Fukuyama

We aim to develop a product with health-promoting benefits for dogs by our original lactobacillus isolated from healthy dogs. New evidence and products will be introduced.

SHINSHU UNIVERSITY
Faculty of Textile Science and Technology
Associate Professor  Dr. Jun Negishi

Healthcare and medical research require 3D cell culture systems that mimic the ECM composition of human tissue. In this study, we introduce a cell introduction method and a scaffold composed of ECM.

DOSHISHA UNIVERSITY
Faculty of Science and Engineering
Professor  Dr. Daisuke KOYAMA

Noncontact manipulation techniques of tissue orientation using ultrasound are introduced. Positions of small objects such as cells and tablets can be controlled temporally and spatially.

KINDAI UNIVERSITY
Faculty of Biology-Oriented Science and Technology
Professor  Dr. Hisashi YOSHIDA

In this presentation, I will talk about biomedical signal processing and its application to the medical and health care fields, particularly a monitoring system for pregnant women and fetuses and the heart rate variability analysis.

KYUSHU UNIVERSITY
School of Engineering
Associate Professor  Dr. Takeshi Mori

"Human orthogonal enzymes" can detect antigens in the biological samples without inactivation of endogenous enzymes. "Oral nanomedicine for allergy treatment" is applicable to oral administration for safe and efficient therapy.

GIFU PHARMACEUTICAL UNIVERSITY
Laboratory of Pharmaceutical Engineering
Professor  Dr. Kohei Tahara

In this study, we developed an oral mucosa-adhesive film containing a high content of polaprezinc for the prevention of stomatitis, which frequently occurs in chemotherapy, especially cancer chemotherapy.

MIE UNIVERSITY
Zebrafish Research Center
Director  Dr. Yasuhito Shimada

We introduce our research achievements using zebrafish as a broad spectrum of disease model for obesity, diabetes, renal function, osteoporosis, cancer xenograft, gut microbiota, fatigue, anxiety, learning ability, and toxicity test.

NIHON UNIVERSITY
School of Medicine
Associate Professor  Dr. Tatsuo KANDA

Hepatitis A virus (HAV) infection causes acute hepatitis and acute liver failure. We have reported that masitinib inhibited HAV internal ribosomal entry site (IRES)-mediated translation and HAV RNA replication.

TOKUSHIMA UNIVERSITY
Department of Applied Chemistry
Associate Professor  Dr. Fumitoshi Yagishita

We have developed N-heteroarenes having photofucntionalities suitable for bioimaging and photodynamic therapy agents. We also developed an environmentally friendly organic synthesis using riboflavin derivatives as organocatalysts.

NIHON UNIVERSITY
School of Pharmacy
Assistant Professor  Dr. Yasuhito Nobushi

Beige adipocyte enriched in mitochondria increases energy expenditure. Inducing beige adipocyte in adipose tissue is attractive strategy for preventing obesity. We identified non-natural flavanone inducing the formation of beige adipocyte.

RESEARCH CENTER FOR MEDICINAL PLANT RESOURCES, NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION
Cltivtion Lab., Tsukuba Division
Head of Lab.  Dr. Hiroyuki Fuchino

We are constructing a large-scale extract library based on plant resources for use in screening for various biological activities in the context of drug discovery. We will introduce the detail and application of this library.

THE UNIVERSITY OF ELECTRO-COMMUNICATIONS
Graduate School of Informatics and Engineering
assistant professor  Dr. Atsushi Nakamura

We introduce a new technique in which the liver of mice emits light through the activation of cytochrome P450. This could be a new diagnostic method to detect diseases by changes in the degree of luminescence.

GIFU PHARMACEUTICAL UNIVERSITY
Laboratory of Organic Chemistry
Associate Professor  Dr. Tsuyoshi Yamada

We have developed the preparation method of Pd precursor for novel heterogeneous Pd catalysts. Various Pd catalysts supported on solid materials can be synthesized and applied to continuous flow reactions.

MEIJI PHARMACEUTICAL UNIVERSITY
Pharmacy
Senior Lecturer  Dr. Motoki Inoue

To realize personalized medicine, diversification of dosage form is necessary. This technology devised a film formulation that utilizes inkjet technology to support various modalities.

JOSAI INTERNATIONAL UNIVERSITY
Faculty of Pharmaceutical Sciences
assistant professor  Dr. Takeshi Oshizaka

Azone has a skin penetration enhancer. It was not approved for treatment because it caused skin irritation following its penetration into the epidermis through the stratum corneum. We designed a formulation with an Azone-mimic structure.

OSAKA UNIVERSITY
SANKEN
Associate Professor  Dr. Tsuyoshi Nishi

We identified the transporters of the lipid mediator S1P and clarified their physiological functions. Furthemore, simple assay system which can be adaptable to multiplate assay for measurement of transport activity was developed

TOKYO METROPOLITAN UNIVERSITY
Department of Applied Chemistry for Environment
Professor  Dr. Hiroyoshi Kawakami

We present the functions of designer stem cells produced by functional nanocarriers and modified exosomes secreted by the cells.

AZABU UNIVERSITY
School of Veterinary Medicine
Assistant Professor  Dr. Masaki Nagane

Polyhydroxybutyrate (PHB) is a polyester of 3-hydroxybutyrate, a short-chain fatty acid. In this presentation, we will introduce the research and development of functional pet foods based on PHB.

HOKKAIDO UNIVERSITY
Faculty of Engineering
Associate Professor  Dr. Kenji Tajima

Bacterial cellulose nanofibers (BCNFs) with very long fibers can be prepared by agitating and culturing cellulose-producing bacterium. In this presentation, the structure, physical properties, and applications of BCNFs will be introduced.

DOSHISHA UNIVERSITY
Faculty of Science and Engineering
Professor  Dr. Yoshiyuki SHIRAKAWA

In order to prevent oil-out in pharmaceutical crystallization processes, it is necessary to understand under what operating conditions it occurs. Therefore, we introduce a prediction simulation for liquid-liquid phase separation.

OSAKA UNIVERSITY
Graduate School of Pharmaceutical Sciences
Associate Professor  Dr. Haruyasu Asahara

We will present our novel plastic surface modification method that enables the addition of biocompatibility and drug loading.